Structure of PDB 3uvu Chain A Binding Site BS01

Receptor Information

>3uvu Chain A (length=425) Species: 10090 (Mus musculus)

GTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLI
PKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLL
ASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTL
ACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADS
CWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV
TGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQ
QVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGI
IEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLD
KIEALQRHENESVYKASLNLIEKYF

Ligand information

>3uvu Chain B (length=19) Species: 9606 (Homo sapiens)

SAKRKEPEPKGSTKKKAKT

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3uvu Structural basis of nuclear import of flap endonuclease 1 (FEN1).
• Resolution: 2.38 Å
• Binding residue (original residue number in PDB): W142 N146 S149 G150 T155 Q181 W184 N188 D192 W231 R238 D270 W273 Y277 G281 N283 T311 R315 V321 T322 N350 W357 N361 A364 E396 W399
• Binding residue (residue number reindexed from 1): W71 N75 S78 G79 T84 Q110 W113 N117 D121 W160 R167 D199 W202 Y206 G210 N212 T240 R244 V250 T251 N279 W286 N290 A293 E325 W328

Enzymatic activity

• Catalytic site (original residue number in PDB): T151 A163 N361 R366 Q367
• Catalytic site (residue number reindexed from 1): T80 A92 N290 R295 Q296

Gene Ontology

Molecular Function

• GO:0061608 nuclear import signal receptor activity

Biological Process

• GO:0006606 protein import into nucleus

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3uvu, PDBe:3uvu, PDBj:3uvu
• PDBsum: 3uvu
• PubMed: 22751659
• UniProt: P52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)