Structure of PDB 3uq2 Chain A Binding Site BS01

Receptor Information
>3uq2 Chain A (length=318) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSI
PGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMW
YQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKA
AQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLR
QEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFT
GSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGAKVGPGRVLPTPTEK
DVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3uq2 The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Resolution2.25 Å
Binding residue
(original residue number in PDB)		W274 Q372 V462 K463 G464 K472 R514 R517 K521 L527 S528 H530 H541
Binding residue
(residue number reindexed from 1)		W22 Q120 V210 K211 G212 K215 R257 R260 K264 L270 S271 H273 H284
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D175 D177 D233
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3uq2, PDBe:3uq2, PDBj:3uq2
PDBsum3uq2
PubMed22584622
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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