Structure of PDB 3upq Chain A Binding Site BS01

Receptor Information
>3upq Chain A (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACS
IPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQM
WYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQK
AAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSL
RQEGFLTDDLVKGETKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYF
TGSAHFNRSMRALAKTKGMSLSEHALSTAVGRVLPTPTEKDVFRLLGLPY
REPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB3upq The catalytic cycle for ribonucleotide incorporation by human DNA Pol lambda
Resolution1.95 Å
Binding residue
(original residue number in PDB)		W274 V462 K463 G464 K472 R514 R517 K521 L527 E529 H530
Binding residue
(residue number reindexed from 1)		W23 V211 K212 G213 K216 R258 R261 K265 L271 E273 H274
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D176 D178 D234
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3upq, PDBe:3upq, PDBj:3upq
PDBsum3upq
PubMed22584622
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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