Structure of PDB 3uo7 Chain A Binding Site BS01

Receptor Information
>3uo7 Chain A (length=181) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPDILTFNLDIVIIGIAPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQ
LNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKY
QPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSS
SARCAQFPRAQDKVHYYIKLKDLRDQLKGIE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3uo7 Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Resolution3.002 Å
Binding residue
(original residue number in PDB)		K246 A274 A277 P280
Binding residue
(residue number reindexed from 1)		K124 A152 A155 P158
Enzymatic activity
Catalytic site (original residue number in PDB) H151
Catalytic site (residue number reindexed from 1) H29
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:3uo7, PDBe:3uo7, PDBj:3uo7
PDBsum3uo7
PubMed22327402
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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