Structure of PDB 3uc3 Chain A Binding Site BS01

Receptor Information
>3uc3 Chain A (length=272) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDMPIMHDSDRYDFVKDIGSGNFGVARLMRDKLTKELVAVKYIERGAAID
ENVQREIINHRSLRHPNIVRFKEVILTPTHLAIIMEYASGGELYERICNA
GRFSEDEARFFFQQLLSGVSYCHSMQICHRDLKLENTLLDGSPAPRLKIC
DFGYSPAYIAPEVLLRQEYDGKIADVWSCGVTLYVMLVGAYPFEPRDYRK
TIQRILSVKYSIPDDIRISPECCHLISRIFVADPATRISIPEIKTHSWFL
KNLPADQSLDTIMQIISEATIP
Ligand information
Ligand IDCO
InChIInChI=1S/Co/q+2
InChIKeyXLJKHNWPARRRJB-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Co+2]
CACTVS 3.341[Co++]
FormulaCo
NameCOBALT (II) ION
ChEMBL
DrugBankDB14205
ZINC
PDB chain3uc3 Chain A Residue 364 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3uc3 Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		Q136 I137 C138
Binding residue
(residue number reindexed from 1)		Q126 I127 C128
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D141 K143 N146 D161
Catalytic site (residue number reindexed from 1) D131 K133 N136 D151
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0044024 histone H2AS1 kinase activity
GO:0106310 protein serine kinase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0006468 protein phosphorylation
GO:0006970 response to osmotic stress
GO:0009414 response to water deprivation
GO:0009651 response to salt stress
GO:0009737 response to abscisic acid
GO:0009738 abscisic acid-activated signaling pathway
GO:0009739 response to gibberellin
GO:0010029 regulation of seed germination
GO:0016310 phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009536 plastid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3uc3, PDBe:3uc3, PDBj:3uc3
PDBsum3uc3
PubMed22160701
UniProtQ39193|SRK2I_ARATH Serine/threonine-protein kinase SRK2I (Gene Name=SRK2I)

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