Structure of PDB 3ua7 Chain A Binding Site BS01

Receptor Information

>3ua7 Chain A (length=63) Species: 9606 (Homo sapiens)

GTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGET
GYIPSNYVAPVDS

Ligand information

>3ua7 Chain E (length=8)

APPIPPPR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3ua7 The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein.
• Resolution: 1.5 Å
• Binding residue (original residue number in PDB): Y91 R96 D118 W119 N136 Y137
• Binding residue (residue number reindexed from 1): Y11 R16 D38 W39 N56 Y57

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:3ua7, PDBe:3ua7, PDBj:3ua7
• PDBsum: 3ua7
• PubMed: 22868769
• UniProt: P06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)