Structure of PDB 3u7g Chain A Binding Site BS01

Receptor Information
>3u7g Chain A (length=377) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGWESLKKLLVFTASGVKPQGKVAAFALDGTLITTRSGKVFPTSPSDWRI
LYPEIPKKLQELAAEGYKLVIFTNQMGIGRGKLPAEVFKGKVEAVLEKLG
VPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFVGDAAGRL
ANWAPGRKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPR
TISSAGPLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHV
NRDTLGSWQRCVSSCQAALRQGKRVVIDNTNPDVPSRARYIQCAKDAGVP
CRCFNFCATIEQARHNNRFREMTDPSHAPVSDMVMFSYRKQFEPPTLAEG
FLEILEIPFRLQLDPALQRLYRQFSEG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3u7g Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		D172 V183 F184 N217 Q218 M219 G220 R223 K225 R258 F305
Binding residue
(residue number reindexed from 1)		D29 V40 F41 N74 Q75 M76 G77 R80 K82 R115 F162
Enzymatic activity
Enzyme Commision number 2.7.1.78: polynucleotide 5'-hydroxyl-kinase.
3.1.3.32: polynucleotide 3'-phosphatase.
Gene Ontology
Molecular Function
GO:0046403 polynucleotide 3'-phosphatase activity
GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3u7g, PDBe:3u7g, PDBj:3u7g
PDBsum3u7g
PubMed22171004
UniProtQ9JLV6|PNKP_MOUSE Bifunctional polynucleotide phosphatase/kinase (Gene Name=Pnkp)

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