Structure of PDB 3tzx Chain A Binding Site BS01

Receptor Information
>3tzx Chain A (length=465) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAEL
ADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAA
GKQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKV
DALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKP
AAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRL
MALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEA
EGKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGR
YIKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVAL
MQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTL
FSRASGPQDYANIPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3tzx Biochemical and structural study of the atypical acyltransferase domain from the mycobacterial polyketide synthase pks13
Resolution2.3 Å
Binding residue
(original residue number in PDB)		L624 L678 H680 P699 N700 F702 P1013 Q1019 S1027
Binding residue
(residue number reindexed from 1)		L30 L84 H86 P105 N106 F108 P419 Q425 S433
Enzymatic activity
Catalytic site (original residue number in PDB) S801 L802 R826 H909 G962
Catalytic site (residue number reindexed from 1) S207 L208 R232 H315 G368
Enzyme Commision number 2.3.1.-
Gene Ontology
Molecular Function
GO:0016740 transferase activity

View graph for
Molecular Function
External links
PDB RCSB:3tzx, PDBe:3tzx, PDBj:3tzx
PDBsum3tzx
PubMed22825853
UniProtO53579

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