Structure of PDB 3twy Chain A Binding Site BS01

Receptor Information
>3twy Chain A (length=137) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPK
NESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDF
MGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPE
Ligand information
Ligand IDPB
InChIInChI=1S/Pb/q+2
InChIKeyRVPVRDXYQKGNMQ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.370[Pb++]
valence
OpenEye OEToolkits 1.7.2[Pb+2]
FormulaPb
NameLEAD (II) ION
ChEMBL
DrugBank
ZINC
PDB chain3twy Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3twy Pb2+ as Modulator of Protein-Membrane Interactions.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		D187 D193 D246 W247 D248
Binding residue
(residue number reindexed from 1)		D32 D38 D91 W92 D93
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:3twy, PDBe:3twy, PDBj:3twy
PDBsum3twy
PubMed21615172
UniProtP05696|KPCA_RAT Protein kinase C alpha type (Gene Name=Prkca)

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