Structure of PDB 3twx Chain A Binding Site BS01
Receptor Information
>3twx Chain A (length=158) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
MGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY
NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN
VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD
TDIQDLLR
Ligand information
>3twx Chain C (length=12) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
QRESPDGQSFRS
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
3twx
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 N565 S568 Y569 H571 D589 W591 F593 E598
Binding residue
(residue number reindexed from 1)
R39 S41 F46 G49 Y50 L74 N79 S82 Y83 H85 D103 W105 F107 E112
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twx
,
PDBe:3twx
,
PDBj:3twx
PDBsum
3twx
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
[
Back to BioLiP
]
