Structure of PDB 3tww Chain A Binding Site BS01
Receptor Information
>3tww Chain A (length=157) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
>3tww Chain C (length=12) Species:
9606
(Homo sapiens) [
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QRQSPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3tww
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
2.0 Å
Binding residue
(original residue number in PDB)
R525 S527 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598
Binding residue
(residue number reindexed from 1)
R38 S40 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3tww
,
PDBe:3tww
,
PDBj:3tww
PDBsum
3tww
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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