Structure of PDB 3twu Chain A Binding Site BS01
Receptor Information
>3twu Chain A (length=160) Species:
9606
(Homo sapiens) [
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NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR
VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA
DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD
IQDLLRGDAA
Ligand information
>3twu Chain B (length=13) Species:
9606
(Homo sapiens) [
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VARPPPIGAEVPD
Receptor-Ligand Complex Structure
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PDB
3twu
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.8 Å
Binding residue
(original residue number in PDB)
R525 F532 G535 Y536 N537 L560 N565 S568 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)
R37 F44 G47 Y48 N49 L72 N77 S80 Y81 H83 D101 W103 F105 E110 K116
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twu
,
PDBe:3twu
,
PDBj:3twu
PDBsum
3twu
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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