Structure of PDB 3twt Chain A Binding Site BS01
Receptor Information
>3twt Chain A (length=156) Species:
9606
(Homo sapiens) [
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NSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNR
VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVA
DLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTD
IQDLLR
Ligand information
>3twt Chain E (length=12) Species:
9606
(Homo sapiens) [
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QRPPPIGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twt
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
R525 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598
Binding residue
(residue number reindexed from 1)
R37 F44 G47 Y48 L72 N77 Y81 H83 D101 W103 F105 E110
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twt
,
PDBe:3twt
,
PDBj:3twt
PDBsum
3twt
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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