Structure of PDB 3twr Chain A Binding Site BS01
Receptor Information
>3twr Chain A (length=157) Species:
9606
(Homo sapiens) [
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SEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLRGD
Ligand information
>3twr Chain E (length=13) Species:
9606
(Homo sapiens) [
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LQRSPPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twr
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.55 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598
Binding residue
(residue number reindexed from 1)
R36 S38 F43 G46 Y47 L71 N76 Y80 H82 D100 W102 F104 E109
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twr
,
PDBe:3twr
,
PDBj:3twr
PDBsum
3twr
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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