Structure of PDB 3tup Chain A Binding Site BS01

Receptor Information
>3tup Chain A (length=404) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSVVELLGKSYPQDDHSNLTRKVLTRVGRNLHNQQHHPLWLIKERVKEHF
YKQYVGRFGTPLFSVYDNLSPVVTTWQNFDSLLIPADHPSRKKGDNYYLN
RTHMLRAHTSAHQWDLLHAGLDAFLVVGDVYRRDQIDSQHYPIFHQLEAV
RLFSKHELFAGIKDGESLQLFEQSSRSAHKQETHTMEAVKLVEFDLKQTL
TRLMAHLFGDELEIRWVDCYFPFTHPSFEMEINFHGEWLEVLGCGVMEQQ
LVNSAGAQDRIGWAFGLGLERLAMILYDIPDIRLFWCEDERFLKQFCVSN
INQKVKFQPLSKYPAVINDISFWLPSENYAENDFYDLVRTIGGDLVEKVD
LIDKFVHPKTHKTSHCYRITYRHMERTLSQREVRHIHQALQEAAVQLLGV
EGRF
Ligand information
>3tup Chain T (length=74) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gccgagguagcucaguugguagagcaugcgacugaaaaucgcagugucgg
cgguucgauucugcuccucggcac
<<<<<<<..<<<<........>>>>.<<<<<.......>>>>>.....<<
<<<.......>>>>>>>>>>>>..
Receptor-Ligand Complex Structure
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PDB3tup Crystal Structure of Human Mitochondrial PheRS Complexed with tRNA(Phe) in the Active "Open" State.
Resolution3.05 Å
Binding residue
(original residue number in PDB)		K33 D145 Q146 R294 K323 P325 A326 V327 I328 N329 D330 S332 D364 F366 C377 Q391 R395 R414
Binding residue
(residue number reindexed from 1)		K22 D134 Q135 R283 K312 P314 A315 V316 I317 N318 D319 S321 D353 F355 C366 Q380 R384 R403
Enzymatic activity
Catalytic site (original residue number in PDB) G105 H119 R143 Q157 T235 A275
Catalytic site (residue number reindexed from 1) G94 H108 R132 Q146 T224 A264
Enzyme Commision number 6.1.1.20: phenylalanine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004826 phenylalanine-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006432 phenylalanyl-tRNA aminoacylation
GO:0008033 tRNA processing
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Biological Process
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Cellular Component
External links
PDB RCSB:3tup, PDBe:3tup, PDBj:3tup
PDBsum3tup
PubMed22137894
UniProtO95363|SYFM_HUMAN Phenylalanine--tRNA ligase, mitochondrial (Gene Name=FARS2)

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