Structure of PDB 3tpx Chain A Binding Site BS01

Receptor Information
>3tpx Chain A (length=84) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIV
YCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
Ligand information
Receptor-Ligand Complex Structure
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PDB3tpx An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		K51 L54 F55 G58 I61 Y67 Q72 H73 V93 K94 H96 I99 Y100
Binding residue
(residue number reindexed from 1)		K26 L29 F30 G33 I36 Y42 Q47 H48 V68 K69 H71 I74 Y75
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3tpx, PDBe:3tpx, PDBj:3tpx
PDBsum3tpx
PubMed22694121
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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