Structure of PDB 3tfy Chain A Binding Site BS01

Receptor Information

>3tfy Chain A (length=155) Species: 9606 (Homo sapiens)

MKGSRIELGDVTPHNIKQLKRLNQVIFPVSYNDKFYKDVLEVGELAKLAY
FNDIAVGAVCCRVDHSQNQKRLYIMTLGCLAPYRRLGIGTKMLNHVLNIC
EKDGTFDNIYLHVQISNESAIDFYRKFGFEIIETKKNYYKRIEPADAHVL
QKNLK

Ligand information

>3tfy Chain D (length=4) Species: 9606 (Homo sapiens)

MLGP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3tfy Structure of a Ternary Naa50p (NAT5/SAN) N-terminal Acetyltransferase Complex Reveals the Molecular Basis for Substrate-specific Acetylation.
• Resolution: 2.75 Å
• Binding residue (original residue number in PDB): P28 Y31 Y73 M75 H112 Y139
• Binding residue (residue number reindexed from 1): P28 Y31 Y73 M75 H112 Y139

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.258: N-terminal methionine N(alpha)-acetyltransferase NatE.

Gene Ontology

Molecular Function

• GO:0004596 peptide alpha-N-acetyltransferase activity
• GO:0005515 protein binding
• GO:0010485 histone H4 acetyltransferase activity
• GO:0016746 acyltransferase activity
• GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
• GO:0061733 peptide-lysine-N-acetyltransferase activity
• GO:0120518 peptide-methionine-alpha-N-acetyltransferase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006474 N-terminal protein amino acid acetylation
• GO:0007064 mitotic sister chromatid cohesion
• GO:0034087 establishment of mitotic sister chromatid cohesion
• GO:0071962 mitotic sister chromatid cohesion, centromeric

Cellular Component

• GO:0005634 nucleus
• GO:0005730 nucleolus
• GO:0005737 cytoplasm
• GO:0005829 cytosol
• GO:0031415 NatA complex
• GO:0070062 extracellular exosome

External links

• PDB: RCSB:3tfy, PDBe:3tfy, PDBj:3tfy
• PDBsum: 3tfy
• PubMed: 21900231
• UniProt: Q9GZZ1|NAA50_HUMAN N-alpha-acetyltransferase 50 (Gene Name=NAA50)