Structure of PDB 3tc3 Chain A Binding Site BS01

Receptor Information
>3tc3 Chain A (length=289) Species: 330779 (Sulfolobus acidocaldarius DSM 639) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMRVGYVSTNYSLGCKADKTIKLSSLSEERVLKVSSSNLLCLKNILEWNL
KHEILFFRISSNTIPLASHPKFHVNWKDKLSHILGDIGDFIKENSIRISM
HPGQYVVLNSVREEVVRSSIMELKYHADLLDSMGIEGKIQIHVGSSMNGK
EESLNRFIENFRKLPSNISKRLVIENDDKVFSVKDCLWISERTGIPVIFD
NLHHSILNNGESLNDALSLVRRTWKDRPMIDYSEQEPGEKPGVHATTINE
ENFRRFVNEVDEVDIMLEVKDKEISALKAVKVLKELNKL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3tc3 Chain A Residue 290 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3tc3 UV damage endonuclease employs a novel dual-dinucleotide flipping mechanism to recognize different DNA lesions.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		E174 D199 D230 E267
Binding residue
(residue number reindexed from 1)		E175 D200 D231 E268
Annotation score4
Enzymatic activity
Enzyme Commision number 3.-.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0009411 response to UV

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Molecular Function
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Biological Process
External links
PDB RCSB:3tc3, PDBe:3tc3, PDBj:3tc3
PDBsum3tc3
PubMed23221644
UniProtQ4J9T1

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