Structure of PDB 3tbh Chain A Binding Site BS01

Receptor Information

>3tbh Chain A (length=318) Species: 5661 (Leishmania donovani)

AAPFDKSKNVAQSIDQLIGQTPALYLNKLNNTKAKVVLKMECENPMASVK
DRLGFAIYDKAEKEGKLIPGKSIVVESSSGNTGVSLAHLGAIRGYKVIIT
MPESMSLERRCLLRIFGAEVILTPAALGMKGAVAMAKKIVAANPNAVLAD
QFATKYNALIHEETTGPEIWEQTNHNVDCFIAGVGTGGTLTGVARALKKM
GSHARIVAVEPTESPVLSGGKPGPHKIQGIGPGFVPDVLDRSLIDEVLCV
AGDDAIETALKLTRSDGVFCGFSGGANVYAALKIAERPEMEGKTIVTVIP
SFGERYLSTTLYRSVRDE

Ligand information

>3tbh Chain B (length=5) Species: 5661 (Leishmania donovani)

DGSGI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3tbh Crystal structure of O-Acetyl Serine Sulfhydrylase in complex with octapeptide derived from Serine Acetyl Transferase of Leishmania donovani
• Resolution: 1.68 Å
• Binding residue (original residue number in PDB): S79 S80 T83 M130 Q152 P225 H226 G230 P233
• Binding residue (residue number reindexed from 1): S78 S79 T82 M129 Q151 P224 H225 G229 P232

Enzymatic activity

• Catalytic site (original residue number in PDB): K51 S274
• Catalytic site (residue number reindexed from 1): K50 S273
• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity

Biological Process

• GO:0006535 cysteine biosynthetic process from serine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3tbh, PDBe:3tbh, PDBj:3tbh
• PDBsum: 3tbh
• UniProt: G1C2I2