Structure of PDB 3t6y Chain A Binding Site BS01

Receptor Information
>3t6y Chain A (length=150) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MHLKIVCLSDEVREMYKNHKGDSGLDLFIVKDEVLKPKSTTFVKLGIKAI
ALQYKSNYYYKSNIVNTSFLLFPRSSISKTPLRLANSIGLIDAGYRGEII
AALDNTSDQEYHIKKNDKLVQLVSFTGEPLSFELVEELDETSRGEGGFGS
Ligand information
Receptor-Ligand Complex Structure
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PDB3t6y Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		K42 T44 D121
Binding residue
(residue number reindexed from 1)		K38 T40 D104
Enzymatic activity
Catalytic site (original residue number in PDB) S27 R91 S93 L99 D109
Catalytic site (residue number reindexed from 1) S23 R74 S76 L82 D92
Enzyme Commision number 3.6.1.23: dUTP diphosphatase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004170 dUTP diphosphatase activity
GO:0016787 hydrolase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006226 dUMP biosynthetic process
GO:0006260 DNA replication
GO:0006399 tRNA metabolic process
GO:0009117 nucleotide metabolic process
GO:0046081 dUTP catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3t6y, PDBe:3t6y, PDBj:3t6y
PDBsum3t6y
PubMed22049550
UniProtQ8II92

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