Structure of PDB 3szq Chain A Binding Site BS01

Receptor Information
>3szq Chain A (length=199) Species: 284812 (Schizosaccharomyces pombe 972h-) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSFRDNLKVYIESPESYKNVIYYDDDVVLVRDMFPKSKMHLLLMTRDPHL
THVHPLEIMMKHRSLVEKLVSYVQGDLSGLIFDEARNCLSQQLTNEALCN
YIKVGFHAGPSMNNLHLHIMTLDHVSPSLKNSAHYISFTSPFFVKIDTPT
SNLPTRGTLTSLFQEDLKCWRCGETFGRHFTKLKAHLQEEYDDWLDKSV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3szq Structure of an aprataxin-DNA complex with insights into AOA1 neurodegenerative disease.
Resolution2.353 Å
Binding residue
(original residue number in PDB)		F34 F65 K67 S142 M143 K161 H165 S229 V230
Binding residue
(residue number reindexed from 1)		F3 F34 K36 S111 M112 K130 H134 S198 V199
Binding affinityPDBbind-CN: Kd=190nM
Enzymatic activity
Enzyme Commision number 3.6.1.71: adenosine-5'-diphospho-5'-[DNA] diphosphatase.
3.6.1.72: DNA-3'-diphospho-5'-guanosine diphosphatase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:3szq, PDBe:3szq, PDBj:3szq
PDBsum3szq
PubMed21984210
UniProtO74859|APTX_SCHPO Aprataxin-like protein (Gene Name=hnt3)

[Back to BioLiP]