Structure of PDB 3syo Chain A Binding Site BS01

Receptor Information
>3syo Chain A (length=309) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IQRYVRKDGKCNVHHYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFG
MIWWLIAYIRGCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIIL
LLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCL
MFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDR
LFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQ
ARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYETSTPSLSAKEL
AELANRAES
Ligand information
Ligand IDNA
InChIInChI=1S/Na/q+1
InChIKeyFKNQFGJONOIPTF-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Na+]
FormulaNa
NameSODIUM ION
ChEMBL
DrugBankDB14516
ZINC
PDB chain3syo Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3syo Crystal Structure of the Mammalian GIRK2 K(+) Channel and Gating Regulation by G Proteins, PIP(2), and Sodium.
Resolution3.54 Å
Binding residue
(original residue number in PDB)		D228 R230 N231 S232 V276
Binding residue
(residue number reindexed from 1)		D156 R158 N159 S160 V204
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005242 inward rectifier potassium channel activity
Biological Process
GO:0006813 potassium ion transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3syo, PDBe:3syo, PDBj:3syo
PDBsum3syo
PubMed21962516
UniProtP48542|KCNJ6_MOUSE G protein-activated inward rectifier potassium channel 2 (Gene Name=Kcnj6)

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