Structure of PDB 3spa Chain A Binding Site BS01

Receptor Information
>3spa Chain A (length=941) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QLSGQQQRLLAFFKCCLLTDQLPLAHHLLVVHHGQRQKRKLLTLDMYNAV
MLGWARQGAFKELVYVLFMVKDAGLTPDLLSYAAALQCMGRQDQDAGTIE
RCLEQMSQEGLKLQALFTAVLLSEEDRATVLKAVHKVKPTFSLPPQLPPP
VNTSKLLRDVYAKDGRVSYPKLHLPLKTLQCLFEKQLHMELASRVCVVSV
EKPTLPSKEVKHARKTLKTLRDQWEKALCRALRETKNRLEREVYEGRFSL
YPFLCLLDEREVVRMLLQVLQALPAQGESFTTLARELSARTFSRHVVQRQ
RVSGQVQALQNHYRKYLCLLASDAEVPEPCLPRQYWEALGAPEALREQPW
PLPVQMELGKLLAEMLVQATQMPCVPVLYHVYSQQIGILKPHPAYVQLLE
KAAEPTLTFEAVDVPMLCPPLPWTSPHSGAFLLSPTKLMRTVEGATQHQE
LLETCPPTALHGALDALTQLGNCAWRVNGRVLDLVLQLFQAKGCPQLGVP
APPREMHSLRAEALYRLSLAQHLRDRVFWLPHNMDFRGRTYPCPPHFNHL
GSDVARALLEFAQGRPLGPHGLDWLKIHLVNLTGLKKREPLRKRLAFAEE
VMDDILDSADQPLTGRKWWMGAEEPWQTLACCMEVANAVRASDPAAYVSH
LPVHQDGSCNGLQHYAALGRDSVGAASVNLEPSDVPQDVYSGVAAQVEVF
RRQDAQRGMRVAQVLEGFITRKVVKQTVMTVVYGVTRYGGRLQIEKRLRE
LSDFPQEFVWEASHYLVRQVFKSLQEMFSGTRAIQHWLTESARLISHMGS
VVEWVTPLGVPVIQPYRLDKPNTRKQKNGFPPNFIHSLDSSHMMLTALHC
YRKGLTFVSVHDCYWTHAADVSVMNQVCREQFVRLHSEPILQDLSRFLVK
RFCSEPQKILEASQLKETLQAVPKPGAFDLEQVKRSTYFFS
Ligand information
Receptor-Ligand Complex Structure
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PDB3spa Structure of human mitochondrial RNA polymerase
Resolution2.5 Å
Binding residue
(original residue number in PDB)		F285 Q322
Binding residue
(residue number reindexed from 1)		F68 Q105
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0001018 mitochondrial promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003896 DNA primase activity
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006269 DNA replication, synthesis of primer
GO:0006351 DNA-templated transcription
GO:0006390 mitochondrial transcription
GO:0006391 transcription initiation at mitochondrial promoter
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0032991 protein-containing complex
GO:0034245 mitochondrial DNA-directed RNA polymerase complex
GO:0042645 mitochondrial nucleoid

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3spa, PDBe:3spa, PDBj:3spa
PDBsum3spa
PubMed21947009
UniProtO00411|RPOM_HUMAN DNA-directed RNA polymerase, mitochondrial (Gene Name=POLRMT)

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