Structure of PDB 3sov Chain A Binding Site BS01
Receptor Information
>3sov Chain A (length=306) Species:
9606
(Homo sapiens) [
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APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSD
VSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRI
EVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMD
GSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV
VKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPM
DIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN
GKTCKD
Ligand information
>3sov Chain Z (length=7) Species:
9606
(Homo sapiens) [
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LPNAIGR
Receptor-Ligand Complex Structure
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PDB
3sov
Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Resolution
1.27 Å
Binding residue
(original residue number in PDB)
R28 E51 D52 S71 D98 R141 W157 W183 N185 H226 W242
Binding residue
(residue number reindexed from 1)
R9 E32 D33 S52 D79 R122 W138 W164 N166 H207 W223
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3sov
,
PDBe:3sov
,
PDBj:3sov
PDBsum
3sov
PubMed
21944579
UniProt
O75581
|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)
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