Structure of PDB 3soq Chain A Binding Site BS01
Receptor Information
>3soq Chain A (length=305) Species:
9606
(Homo sapiens) [
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APLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSD
VSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRI
EVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMD
GSSRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAV
VKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPM
DIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLEN
GKTCK
Ligand information
>3soq Chain Z (length=7) Species:
9606
(Homo sapiens) [
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NSNAIKN
Receptor-Ligand Complex Structure
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PDB
3soq
Wnt antagonists bind through a short peptide to the first beta-propeller domain of LRP5/6.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
R28 V70 L95 D98 E115 R141 W157 W183 N185 H226 W242
Binding residue
(residue number reindexed from 1)
R9 V51 L76 D79 E96 R122 W138 W164 N166 H207 W223
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:3soq
,
PDBe:3soq
,
PDBj:3soq
PDBsum
3soq
PubMed
21944579
UniProt
O75581
|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)
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