Structure of PDB 3snp Chain A Binding Site BS01

Receptor Information
>3snp Chain A (length=850) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNPFAYLAEPLDPAQPGKKFFNLNKLDYSRYGRLPFSIRVLLEAAVRNCD
KFLVKKEDIENILNWNVTQHMNIEVPFKPARVILQDFTGVPSVVDFAAMR
DAVKKLGGDPEKINPICPVDLVIDHSEFERNRERFEFLKWGSKAFRNMRI
IPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGW
GVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLR
QVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATATFFPVDEVSIKY
LVQTGRDESKVKQIRKYLQAVGMFRDYSDPSQDPDFTQVVELDLKTVVPC
CSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYND
SEFTLSHGSVVIAAITSSTNTSNPSVMLGAGLLAKKAVDAGLNVKPYVKT
SLSPGSGVVTYYLRESGVMPYLSQLGFDVVPLPEPVVEAITQGDLVAVGV
LSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGTNAKG
QQVFLRDIWPTREEIQAVERQYVIPGMFTEVYQKIETVNASWKLYLWNPK
STYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARN
SPAARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNRFLNKQAP
QTIHLPSGETLDVFDAAERYQQEGHPLIVLAGKEYGSGSSRDWAAKGPFL
LGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADSLGLTGRERYTIII
PENLTPRMHVQVKLDTGKTFQAVIRFDTDVELTYFHNGGILNYMIRKMAK
Ligand information
>3snp Chain C (length=30) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
guucuugcuucaacaguguuugaacggaac
<<<<<.<.<<<<<......>>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB3snp Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H126 S127 H207 L262 R269 N298 E302 S371 P376 K379 T438 N439 T440 N535 R536 L551 S681 P682 A683 G684 N685 R688 R704 S708 G710 R713 R780
Binding residue
(residue number reindexed from 1)		H125 S126 H188 L243 R250 N279 E283 S352 P357 K360 T419 N420 T421 N504 R505 L520 S642 P643 A644 G645 N646 R649 R665 S669 G671 R674 R741
Enzymatic activity
Catalytic site (original residue number in PDB) D125 H126 D205 R536 S778 R780
Catalytic site (residue number reindexed from 1) D124 H125 D186 R505 S739 R741
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0010040 response to iron(II) ion
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3snp, PDBe:3snp, PDBj:3snp
PDBsum3snp
PubMed17185597
UniProtQ01059|ACOHC_RABIT Cytoplasmic aconitate hydratase (Gene Name=ACO1)

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