Structure of PDB 3sn2 Chain A Binding Site BS01

Receptor Information
>3sn2 Chain A (length=848) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SNPFAYLAEPLDPAQPGKKFFNLNKLDYSRYGRLPFSIRVLLEAAVRNCD
KFLVKKEDIENILNWNVTQHMNIEVPFKPARVILQDFTGVPSVVDFAAMR
DAVKKLGGDPEKINPICPVDLVIDFERNRERFEFLKWGSKAFRNMRIIPP
GSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGVLGWGVG
GIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVG
VVGKFVEFFGPGVAQLSIADRATIANMCPEYGATATFFPVDEVSIKYLVQ
TGRDESKVKQIRKYLQAVGMFRDYSDPSQDPDFTQVVELDLKTVVPCCSG
PKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPDHHNDHKTFIYNDSEF
TLSHGSVVIAAITSSTNTSNPSVMLGAGLLAKKAVDAGLNVKPYVKTSLS
PGSGVVTYYLRESGVMPYLSQLGFDVVPLPEPVVEAITQGDLVAVGVLSG
NRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGTNAKGQQV
FLRDIWPTREEIQAVERQYVIPGMFTEVYQKIETVNASSDKLYLWNPKST
YIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSP
AARYLTNRGLTPREFNSYGSRRGNDAIMARGTFANIRLLNRFLNKQAPQT
IHLPSGETLDVFDAAERYQQEGHPLIVLAGKEYGSGSSRDWAAKGPFLLG
IKAVLAESYERIHRSNLVGMGVIPLEYLPGENADSLGLTGRERYTIIIPE
NLTPRMHVQVKLDTGKTFQAVIRFDTDVELTYFHNGGILNYMIRKMAK
Ligand information
>3sn2 Chain B (length=29) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gauuaucggaagcagugccuuccauaauc
<<<<<<.<<<<<......>>>>>>>>>>>
Receptor-Ligand Complex Structure
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PDB3sn2 Accommodating variety in iron-responsive elements: Crystal structure of transferrin receptor 1 B IRE bound to iron regulatory protein 1.
Resolution2.99 Å
Binding residue
(original residue number in PDB)		H207 L262 R269 M299 E302 S371 P376 K379 T438 N439 N535 R536 L551 S681 P682 A683 N685 R688 P703 R704 S708 G710 R713 S778 R780 D781
Binding residue
(residue number reindexed from 1)		H185 L240 R247 M277 E280 S349 P354 K357 T416 N417 N501 R502 L517 S640 P641 A642 N644 R647 P662 R663 S667 G669 R672 S737 R739 D740
Enzymatic activity
Catalytic site (original residue number in PDB) D125 D205 R536 S778 R780
Catalytic site (residue number reindexed from 1) D124 D183 R502 S737 R739
Enzyme Commision number 4.2.1.3: aconitate hydratase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0030350 iron-responsive element binding
GO:0046872 metal ion binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0010040 response to iron(II) ion
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3sn2, PDBe:3sn2, PDBj:3sn2
PDBsum3sn2
PubMed22119729
UniProtQ01059|ACOHC_RABIT Cytoplasmic aconitate hydratase (Gene Name=ACO1)

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