Structure of PDB 3si8 Chain A Binding Site BS01

Receptor Information
>3si8 Chain A (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGII
AVSYEARAFGVTRSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVE
VMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYIE
GLPQGVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIE
RETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKI
RSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGI
EHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKD
RNDNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKN
CNIQTEWSPPLTMLFLCATKFS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3si8 Structure and mechanism of human DNA polymerase eta.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W64 K86 K293 R313 P316 K317 T318 G320 C321 S322 N324 P326 G327 R351
Binding residue
(residue number reindexed from 1)		Q40 Y41 W66 K88 K288 R308 P311 K312 T313 G315 C316 S317 N319 P321 G322 R346
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3si8, PDBe:3si8, PDBj:3si8
PDBsum3si8
PubMed20577208
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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