Structure of PDB 3shw Chain A Binding Site BS01

Receptor Information

>3shw Chain A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRV
NNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFY
IRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVE
RGIIPNKNRAEQLASVQYTQTKFPAYERVVLREAGFLRPVTIFGPIADVA
REKLAREEPDIYQIAKSEPGIIRLHTIKQIIDQDKHALLDVTPNAVDRLN
YAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHH
LFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSE

Ligand information

>3shw Chain B (length=7) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

GKTSVWI

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3shw The Structure of the PDZ3-SH3-GuK Tandem of ZO-1 Suggests a Supramodular Organization of the Conserved MAGUK Family Scaffold Core
Resolution	2.9 Å
Binding residue (original residue number in PDB)	S432 V433 G434 L435 V450 L487 N551 G552
Binding residue (residue number reindexed from 1)	S12 V13 G14 L15 V30 L67 N131 G132

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Cellular Component
GO:0005923	bicellular tight junction

View graph for
Cellular Component

External links

PDB	RCSB:3shw, PDBe:3shw, PDBj:3shw
PDBsum	3shw
PubMed
UniProt	Q07157\|ZO1_HUMAN Tight junction protein ZO-1 (Gene Name=TJP1)

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