Structure of PDB 3s6b Chain A Binding Site BS01

Receptor Information
>3s6b Chain A (length=345) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HLKTIVKKHLSPENFDPTNRKYWVYDDHLKNFVNFKFTGDVRPWPLSKIN
HVPSHIERPDYAISSIPESELIYKRKSDIYVNNEEEIQRIREACILGRKT
LDYAHTLVSPGVTTDEIDRKVHEFIIKNNAYPSTLNYYKFPKSCCTSVNE
IVCHGIPDYRPLKSGDIINIDISVFYKGVHSDLNETYFVGDINDVPKEGK
ELVETCYFSLMEAIKKCKPGMFYKNIGTLIDAYVSKKNFSVVRSYSGHGV
GKLFHSNPTVPHFKKNKAVGIMKPGHVFTIEPMINQGHYSDVLWPDQWTS
ATSDGKLSAQFEHTLLITNNGVEILTKRTQDSPPLGFDTKDELYY
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain3s6b Chain A Residue 370 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3s6b Crystal structure of methionine aminopeptidase 1b from Plasmodium Falciparum, PF10_0150
Resolution1.95 Å
Binding residue
(original residue number in PDB)		D204 H270 E303 E334
Binding residue
(residue number reindexed from 1)		D182 H248 E281 E312
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D193 D204 H270 H277 E303 E334
Catalytic site (residue number reindexed from 1) D171 D182 H248 H255 E281 E312
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:3s6b, PDBe:3s6b, PDBj:3s6b
PDBsum3s6b
PubMed
UniProtQ8IJP2|MAP1B_PLAF7 Methionine aminopeptidase 1b (Gene Name=METAP1b)

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