Structure of PDB 3s3o Chain A Binding Site BS01

Receptor Information
>3s3o Chain A (length=368) Species: 11963 (Human spumaretrovirus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LDAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKI
VLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNK
ASGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYP
TKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLE
FSTPYHPQSSGKVERKHSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTY
SPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPST
PPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDH
LGNNRTVSIDNLKPTSHQ
Ligand information
Receptor-Ligand Complex Structure
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PDB3s3o Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572).
Resolution2.55 Å
Binding residue
(original residue number in PDB)		I112 L113 R114 P115 E207 T210 Q215 S216 G218 K219 R222 D226 R229 S258 P259 K345 N348 R350 T351
Binding residue
(residue number reindexed from 1)		I105 L106 R107 P108 E200 T203 Q208 S209 G211 K212 R215 D219 R222 S251 P252 K338 N341 R343 T344
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.26.4: ribonuclease H.
3.4.23.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:3s3o, PDBe:3s3o, PDBj:3s3o
PDBsum3s3o
PubMed21719464
UniProtP14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)

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