Structure of PDB 3rzx Chain A Binding Site BS01

Receptor Information
>3rzx Chain A (length=427) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGL
IPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISL
LASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLST
LACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLAD
SCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNI
VTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQI
QQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCG
IIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGL
DKIEALQRHENESVYKASLNLIEKYFS
Ligand information
Receptor-Ligand Complex Structure
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PDB3rzx Structural basis of importin-alpha-mediated nuclear transport for Ku70 and Ku80.
Resolution2.61 Å
Binding residue
(original residue number in PDB)		S105 W142 N146 S149 G150 T151 T155 Q181 W184 N188 D192 W231 R238 D270 W273 L307 P308
Binding residue
(residue number reindexed from 1)		S35 W72 N76 S79 G80 T81 T85 Q111 W114 N118 D122 W161 R168 D200 W203 L237 P238
Enzymatic activity
Catalytic site (original residue number in PDB) T151 A163 N361 R366 Q367
Catalytic site (residue number reindexed from 1) T81 A93 N291 R296 Q297
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0061608 nuclear import signal receptor activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3rzx, PDBe:3rzx, PDBj:3rzx
PDBsum3rzx
PubMed21806995
UniProtP52293|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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