Structure of PDB 3rtx Chain A Binding Site BS01

Receptor Information
>3rtx Chain A (length=262) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLKLGAIFLEGITVKGVTQVTTQPKLGEVQQKCHQFCGWEGSGFPGAQPV
SMDKQNIRLLEQKPYKVSWKADGTRYMMLIDGTNEVFMIDRDNSVFHVSN
LEFPFRKDLRMHLSNTLLDGEMIIDKVNGQAVPRYLIYDIIKFNAQPVGD
CDFNIRLQCIEREIISPRHEKMKTGLIDKTQEPFSVRPKQFFDINISRKL
LEGDGLIFQPIGKYKPGRCDDILKWKPPSLNSAYNTAMAVCNSISNPVTK
EMLFEFIDRCAA
Ligand information
Receptor-Ligand Complex Structure
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PDB3rtx Structural insights to how mammalian capping enzyme reads the CTD code.
Resolution2.81 Å
Binding residue
(original residue number in PDB)		R330 K331 F367 Q370 V372 C375 C383 R386 E387
Binding residue
(residue number reindexed from 1)		R106 K107 F143 Q146 V148 C151 C159 R162 E163
Enzymatic activity
Enzyme Commision number 2.7.7.50: mRNA guanylyltransferase.
3.6.1.74: mRNA 5'-phosphatase.
Gene Ontology
Molecular Function
GO:0004484 mRNA guanylyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006370 7-methylguanosine mRNA capping

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Molecular Function
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Biological Process
External links
PDB RCSB:3rtx, PDBe:3rtx, PDBj:3rtx
PDBsum3rtx
PubMed21683636
UniProtO55236|MCE1_MOUSE mRNA-capping enzyme (Gene Name=Rngtt)

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