Structure of PDB 3rnu Chain A Binding Site BS01

Receptor Information

>3rnu Chain A (length=199) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SAQSDLKEVMVLNATESFVYEPKEQKKMFHATVATENEVFRVKVFNIDLK
EKFTPKKIIAIANYVCRNGFLEVYPFTLVADVNADRNMEIPKGLIRSASV
TPKINQLCSQTKGSFVNGVFEVHKKNVRGEFTYYEIQDNTGKMEVVVHGR
LTTINCEEGDKLKLTCFELAPKSGNTGELRSVIHSHIKVIKTRKNAAAS

Ligand information

>3rnu Chain L (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tctctctttgatggcc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3rnu Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor.
Resolution	2.502 Å
Binding residue (original residue number in PDB)	K663 R667 R764
Binding residue (residue number reindexed from 1)	K92 R96 R193

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Biological Process
GO:0002218	activation of innate immune response
GO:0035458	cellular response to interferon-beta

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Biological Process

External links

PDB	RCSB:3rnu, PDBe:3rnu, PDBj:3rnu
PDBsum	3rnu
PubMed	22483801
UniProt	Q16666\|IF16_HUMAN Gamma-interferon-inducible protein 16 (Gene Name=IFI16)

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