Structure of PDB 3rig Chain A Binding Site BS01

Receptor Information

>3rig Chain A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SFTARPSSSMADFRKFFAKAKHIVIISGAGVGGYWRKWQAQDLATPLAFA
HNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNI
DELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEP
GTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC
DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGP
CGTTLPEALA

Ligand information

>3rig Chain C (length=6) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

TARKST

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3rig Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase
Resolution	2.0 Å
Binding residue (original residue number in PDB)	H158 V221 F223 G224 E225 N226 L227 V253 V254 Y255 P256
Binding residue (residue number reindexed from 1)	H116 V179 F181 G182 E183 N184 L185 V211 V212 Y213 P214

Enzymatic activity

Catalytic site (original residue number in PDB)	N141 D143 H158
Catalytic site (residue number reindexed from 1)	N99 D101 H116
Enzyme Commision number	2.3.1.-

Gene Ontology

	Molecular Function
GO:0036054	protein-malonyllysine demalonylase activity
GO:0036055	protein-succinyllysine desuccinylase activity
GO:0070403	NAD+ binding

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Molecular Function

External links

PDB	RCSB:3rig, PDBe:3rig, PDBj:3rig
PDBsum	3rig
PubMed	22076378
UniProt	Q9NXA8\|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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