Structure of PDB 3rc5 Chain A Binding Site BS01

Receptor Information
>3rc5 Chain A (length=198) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEGE
VQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKDL
VGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRPI
SYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTMR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3rc5 Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		H1057 R1123 L1135 K1136 G1137 A1139 F1154 R1155 A1156 A1157 V1158 S1159 T1160 D1168
Binding residue
(residue number reindexed from 1)		H75 R141 L153 K154 G155 A157 F172 R173 A174 A175 V176 S177 T178 D186
Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H75 D99 G155 A157
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3rc5, PDBe:3rc5, PDBj:3rc5
PDBsum3rc5
PubMed21507982
UniProtP27958|POLG_HCV77 Genome polyprotein

[Back to BioLiP]