Structure of PDB 3rc4 Chain A Binding Site BS01

Receptor Information
>3rc4 Chain A (length=199) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMASMKKKGSVVIVGRINLSGDTAYAQQTRGEEGCQETSQTGRDKNQVEG
EVQIVSTATQTFLATSINGVLWTVYHGAGTRTIASPKGPVTQMYTNVDKD
LVGWQAPQGSRSLTPCTCGSSDLYLVTRHADVIPVRRRGDSRGSLLSPRP
ISYLKGSAGGPLLCPAGHAVGIFRAAVSTRGVAKAVDFIPVESLETTMR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3rc4 Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease.
Resolution1.5 Å
Binding residue
(original residue number in PDB)		H1057 L1135 G1137 A1139 F1154 A1156 A1157 V1158 S1159 T1160
Binding residue
(residue number reindexed from 1)		H76 L154 G156 A158 F173 A175 A176 V177 S178 T179
Enzymatic activity
Catalytic site (original residue number in PDB) H1057 D1081 G1137 A1139
Catalytic site (residue number reindexed from 1) H76 D100 G156 A158
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.21.98: hepacivirin.
3.4.22.-
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

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Molecular Function
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Biological Process
External links
PDB RCSB:3rc4, PDBe:3rc4, PDBj:3rc4
PDBsum3rc4
PubMed21507982
UniProtP27958|POLG_HCV77 Genome polyprotein

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