Structure of PDB 3rc0 Chain A Binding Site BS01

Receptor Information

>3rc0 Chain A (length=420) Species: 9606 (Homo sapiens)

LDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVV
PRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRP
YFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIV
LPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEKEPNSPVMVPAA
DILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMY
GFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEM
VGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQKREEGSLTIT
NIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQ
ALQVRYGQKMILHQLLELTS

Ligand information

>3rc0 Chain P (length=6) Species: 9606 (Homo sapiens)

ETFKSI

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3rc0 Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
• Resolution: 2.19 Å
• Binding residue (original residue number in PDB): W122 A222 S224 F225 Q226 P228 N239 P241 N259 L260 Y262 N283 T284 Y285 M288 M296 Y297
• Binding residue (residue number reindexed from 1): W80 A180 S182 F183 Q184 P186 N192 P194 N212 L213 Y215 N236 T237 Y238 M241 M249 Y250

Enzymatic activity

• Enzyme Commision number: 2.1.1.-

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008168 methyltransferase activity
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0051059 NF-kappaB binding
• GO:1904047 S-adenosyl-L-methionine binding

Biological Process

• GO:0018022 peptidyl-lysine methylation
• GO:0018026 peptidyl-lysine monomethylation
• GO:0019827 stem cell population maintenance
• GO:0032088 negative regulation of NF-kappaB transcription factor activity
• GO:0032259 methylation
• GO:0048863 stem cell differentiation
• GO:0050727 regulation of inflammatory response

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:3rc0, PDBe:3rc0, PDBj:3rc0
• PDBsum: 3rc0
• PubMed: 21515635
• UniProt: Q8TBK2|SETD6_HUMAN N-lysine methyltransferase SETD6 (Gene Name=SETD6)