Structure of PDB 3r8x Chain A Binding Site BS01

Receptor Information
>3r8x Chain A (length=309) Species: 632 (Yersinia pestis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMSDSLRIIFAGTPDFAARHLGALLSSQHKIVGVFTQPDRPLTPSPVKIL
AEHHGIPVFQPKSLRPEENQHLVADLNADIMVVVAYGLILPAAVLAMPRL
GCINVHGSLLPRWRGAAPIQRSVWAGDEKTGITIMQMDIGLDTGAMLHKI
ECAIQPEDTSATLYDKLAQLGPQGLLITLQQLAAGTALAEVQNETQATYA
EKLSKEEAKLDWTLSATQLERCIRAFNPWPVSYFIVDEQPIKVWQAQVLP
AGEDAEPGTIIHADKHGIQVATADGVLNITQLQPAGKKAMSAADLLNSRR
EWFIPGSQL
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain3r8x Chain A Residue 320 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3r8x Crystal Structure of Methionyl-tRNA Formyltransferase from Yersinia pestis complexed with L-methionine
Resolution2.256 Å
Binding residue
(original residue number in PDB)		A90 Y91 N109 H111 D147
Binding residue
(residue number reindexed from 1)		A85 Y86 N104 H106 D142
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) H111 D147
Catalytic site (residue number reindexed from 1) H106 D142
Enzyme Commision number 2.1.2.9: methionyl-tRNA formyltransferase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004479 methionyl-tRNA formyltransferase activity
GO:0016740 transferase activity
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0009058 biosynthetic process
GO:0019988 charged-tRNA amino acid modification
GO:0071951 conversion of methionyl-tRNA to N-formyl-methionyl-tRNA
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3r8x, PDBe:3r8x, PDBj:3r8x
PDBsum3r8x
PubMed
UniProtQ8ZJ80|FMT_YERPE Methionyl-tRNA formyltransferase (Gene Name=fmt)

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