Structure of PDB 3qt0 Chain A Binding Site BS01

Receptor Information
>3qt0 Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKSPFVIYDMNSLMMGED
KIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLD
LNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ
DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTE
TDMSLHPLLQEIYKDLY
Ligand information
Receptor-Ligand Complex Structure
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PDB3qt0 Revealing a steroid receptor ligand as a unique PPAR gamma agonist.
Resolution2.496 Å
Binding residue
(original residue number in PDB)		K301 N312 V315 L318 K319 P467 L468 E471
Binding residue
(residue number reindexed from 1)		K91 N102 V105 L108 K109 P257 L258 E261
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qt0, PDBe:3qt0, PDBj:3qt0
PDBsum3qt0
PubMed21986665
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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