Structure of PDB 3qis Chain A Binding Site BS01

Receptor Information
>3qis Chain A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSLELSRREFVFENVKFRQLQKEKFQISNNGQVPCHFSFIPKLNDSQYCK
PWLRAEPFEGYLEPNETVDISLDVYVSKDSVTILNSGEDKIEDILVLHLD
RGKDYFLTISGNYLPSCFGTSLEALCRMKRPIRERPLQVPKEIWLLVDHL
FKYACHQEDLFQTPGMQEELQQIIDCLDTSIPETIPGSNHSVAEALLIFL
EALPEPVICYELYQRCLDSAYDPRICRQVISQLPRCHRNVFRYLMAFLRE
LLKFSEYNSVNANMIATLFTSLLLRPPPSDRQRAIQFLLGFLL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3qis Recognition of the F&H motif by the Lowe syndrome protein OCRL.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		Q733 V734 K736 W739 D743 F746 N834 Y838 A841 F842
Binding residue
(residue number reindexed from 1)		Q138 V139 K141 W144 D148 F151 N239 Y243 A246 F247
Enzymatic activity
Enzyme Commision number 3.1.3.36: phosphoinositide 5-phosphatase.
3.1.3.56: inositol-polyphosphate 5-phosphatase.
3.1.3.86: phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase.
Gene Ontology
Biological Process
GO:0007165 signal transduction

View graph for
Biological Process
External links
PDB RCSB:3qis, PDBe:3qis, PDBj:3qis
PDBsum3qis
PubMed21666675
UniProtQ01968|OCRL_HUMAN Inositol polyphosphate 5-phosphatase OCRL (Gene Name=OCRL)

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