Structure of PDB 3qfj Chain A Binding Site BS01

Receptor Information

>3qfj Chain A (length=275) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAP
WIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMYG
CDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEAA
HVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT
LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGQEQRYTCHVQHEGLPKPLTLRWE

Ligand information

>3qfj Chain C (length=9) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

LLFGFPVYV

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3qfj Disparate degrees of hypervariable loop flexibility control T-cell receptor cross-reactivity, specificity, and binding mechanism.
Resolution	2.29 Å
Binding residue (original residue number in PDB)	Y7 F9 E63 K66 T73 V76 D77 Y84 Y99 Y116 T143 K146 W147 Q155 L156 Y159 W167 Y171
Binding residue (residue number reindexed from 1)	Y7 F9 E63 K66 T73 V76 D77 Y84 Y99 Y116 T143 K146 W147 Q155 L156 Y159 W167 Y171

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:3qfj, PDBe:3qfj, PDBj:3qfj
PDBsum	3qfj
PubMed	22019736
UniProt	P04439\|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)

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