Structure of PDB 3q8m Chain A Binding Site BS01

Receptor Information
>3q8m Chain A (length=335) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRS
ERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIP
YLDAPSEAEASCAALVKAGKVYAAATEDMACLTFGSPVLMRHLTASEAKK
LPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQ
KHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEP
NEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGST
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q8m Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		I44 V46 M65 Y69 R70 R73 S197 E198 R239 G240 G242 R245
Binding residue
(residue number reindexed from 1)		I43 V45 M64 Y68 R69 R72 S196 E197 R238 G239 G241 R244
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:3q8m, PDBe:3q8m, PDBj:3q8m
PDBsum3q8m
PubMed21496641
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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