Structure of PDB 3q7c Chain A Binding Site BS01

Receptor Information

>3q7c Chain A (length=209) Species: 11622 (Lassa virus Josiah) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GFTAGLTYSQLMTLKDAMLQLDPNAKTWMDIEGRPEDPVEIALYQPSSGC
YIHFFREPTDLKQFKQDAKYSHGIDVTDLFATQPGLTSAVIDALPRNMVI
TCQGSDDIRKLLESQGRKDIKLIDIALSKTDSRKYENAVWDQYKDLCHMH
TGVVVEKKKRGGKEEITPHCALMDCIMFDAAVSGGLNTVLRAVLPRDMVF
RTSTPRVVL

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

3q7c Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3q7c Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3' to 5' exonuclease activity essential for immune suppression.
Resolution	1.5 Å
Binding residue (original residue number in PDB)	E399 C506 H509 C529
Binding residue (residue number reindexed from 1)	E40 C147 H150 C170
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.13.-

External links

PDB	RCSB:3q7c, PDBe:3q7c, PDBj:3q7c
PDBsum	3q7c
PubMed	21262835
UniProt	P13699\|NCAP_LASSJ Nucleoprotein (Gene Name=N)

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