Structure of PDB 3q36 Chain A Binding Site BS01

Receptor Information
>3q36 Chain A (length=178) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISLDQIDLLSTKSFPPCMRQLHKALRENHHLRHGGRMQYGLFLKGIGLTL
EQALQFWKQEFIKGKMDPDKFDKGYSYNIRHSFGYTPFSCLKIILSNPPS
QGDYHGCPFRHSDPELLKQKLQSYKISPGGISQILDLVKGTHYQVACQKY
FEMIHNVDDCGFSLNHPNQFFCESQRIL
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain3q36 Chain A Residue 458 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q36 Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase - polymerase alpha switch.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		P285 C287 C367 C384 F386 C424 L441 P444
Binding residue
(residue number reindexed from 1)		P15 C17 C90 C107 F109 C147 L164 P167
Annotation score4
Enzymatic activity
Enzyme Commision number 2.7.7.-
Gene Ontology
Biological Process
GO:0006269 DNA replication, synthesis of primer

View graph for
Biological Process
External links
PDB RCSB:3q36, PDBe:3q36, PDBj:3q36
PDBsum3q36
PubMed21346410
UniProtP49643|PRI2_HUMAN DNA primase large subunit (Gene Name=PRIM2)

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