Structure of PDB 3q23 Chain A Binding Site BS01

Receptor Information

>3q23 Chain A (length=1095) Species: 10752 (Enquatrovirus N4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

EELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAPL
KDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILRS
RLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQTA
VLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLTE
AVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVEN
IVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMFF
GDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLGK
DRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQS
EDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSNQ
NNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVEF
NTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPLY
VEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRST
ADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDIN
LGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDVL
KARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRKG
VLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQTV
GESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFLT
QKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMRV
PMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMNI
GLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEALE
AIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVNL
SIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEARKQ

Ligand information

>3q23 Chain C (length=20) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

ccaaaagaagcggagcttct

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3q23 X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Resolution	1.8 Å
Binding residue (original residue number in PDB)	K114 R119 W129 A171 K173 D177 I181 T202 E205 K267 K268 T269 G271 R318 R421 I675 Y678 S680 K849 K850 E886 A888 D901 R902 R904 V917 A918 P921
Binding residue (residue number reindexed from 1)	K109 R114 W124 A166 K168 D172 I176 T197 E200 K262 K263 T264 G266 R313 R416 I670 Y673 S675 K844 K845 E881 A883 D896 R897 R899 V912 A913 P916

Enzymatic activity

Enzyme Commision number

2.7.7.6: DNA-directed RNA polymerase.

External links

PDB	RCSB:3q23, PDBe:3q23, PDBj:3q23
PDBsum	3q23
PubMed	21321236
UniProt	Q859P9\|RPOLV_BPN4 Virion DNA-directed RNA polymerase (Gene Name=50)

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