Structure of PDB 3q0r Chain A Binding Site BS01

Receptor Information
>3q0r Chain A (length=343) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAE
RQMVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLP
LALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQ
KCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPI
LEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQH
KFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVV
QKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q0r Alternate modes of cognate RNA recognition by human PUMILIO proteins.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q738 R742 Q745 N777 Y778 Q781 Y811 C813 R814 Q817 Q848 N849 H852 Q855 Y885 C887 R888 Q891 Y921 N923 Y924 Q927 S959 N960 E963 Y1000 N1002 Y1003 Q1006 Y1036 H1039
Binding residue
(residue number reindexed from 1)		Q33 R37 Q40 N72 Y73 Q76 Y106 C108 R109 Q112 Q143 N144 H147 Q150 Y180 C182 R183 Q186 Y216 N218 Y219 Q222 S254 N255 E258 Y295 N297 Y298 Q301 Y331 H334
Binding affinityPDBbind-CN: Kd=0.08nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3q0r, PDBe:3q0r, PDBj:3q0r
PDBsum3q0r
PubMed21397187
UniProtQ8TB72|PUM2_HUMAN Pumilio homolog 2 (Gene Name=PUM2)

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