Structure of PDB 3q0p Chain A Binding Site BS01

Receptor Information
>3q0p Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATPAE
RQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSLEQKLALAERIRGHVLS
LALQMYGCRVIQKALEFIPSDQQNEMVRELDGHVLKCVKDQNGNHVVQKC
IECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILE
ELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKF
ASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQK
MIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYY
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q0p Alternate modes of cognate RNA recognition by human PUMILIO proteins.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q860 R864 Q867 F897 N899 Y900 M932 Y933 R936 Q939 H972 R1008 Y1041 N1043 Y1044 K1076 F1077 N1080 E1083 Y1120 N1122 Y1123 Y1156 H1159
Binding residue
(residue number reindexed from 1)		Q33 R37 Q40 F70 N72 Y73 M105 Y106 R109 Q112 H145 R181 Y214 N216 Y217 K249 F250 N253 E256 Y293 N295 Y296 Y329 H332
Binding affinityPDBbind-CN: Kd=0.4nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology

View graph for
Molecular Function
External links
PDB RCSB:3q0p, PDBe:3q0p, PDBj:3q0p
PDBsum3q0p
PubMed21397187
UniProtQ14671|PUM1_HUMAN Pumilio homolog 1 (Gene Name=PUM1)

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