Structure of PDB 3pzp Chain A Binding Site BS01

Receptor Information
>3pzp Chain A (length=440) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQI
TSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDNPELK
DKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKY
RAVSKEVKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIK
QNSVVFGTSAQEVVKEIRFRIEQKTTLTASAGIAPNTMLAKVCSDKNKPN
GQYQILPNRQAVMDFIKDLPIRKVSGIGKVTEKMLKALGIITCTELYQQR
ALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVERTFSEINKAEE
QYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3pzp Role of human DNA polymerase kappa in extension opposite from a cis-syn thymine dimer.
Resolution3.336 Å
Binding residue
(original residue number in PDB)		S196 E199 G356 I357 G358 V360 T361 T469 R470 A471 S472 T473
Binding residue
(residue number reindexed from 1)		S172 E175 G276 I277 G278 V280 T281 T389 R390 A391 S392 T393
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3pzp, PDBe:3pzp, PDBj:3pzp
PDBsum3pzp
PubMed21354175
UniProtQ9UBT6|POLK_HUMAN DNA polymerase kappa (Gene Name=POLK)

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