Structure of PDB 3pw7 Chain A Binding Site BS01

Receptor Information

>3pw7 Chain A (length=343) Species: 2287 (Saccharolobus solfataricus)

HHMIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANY
EARKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEK
IEIASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNK
VFAKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLG
INKLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRI
VTMKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSR
GRTFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI

Ligand information

>3pw7 Chain B (length=16)

attgaatccttccccc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3pw7 Bypass of Aflatoxin B(1) Adducts by the Sulfolobus solfataricus DNA Polymerase IV.
• Resolution: 2.9 Å
• Binding residue (original residue number in PDB): F36 S37 R39 F40 S43 G44 A45 G221 E222 A223 R245 K246 S247 I248 G249 R250 I251 T253 L296 R334 R335 R339
• Binding residue (residue number reindexed from 1): F35 S36 R38 F39 S42 G43 A44 G220 E221 A222 R244 K245 S246 I247 G248 R249 I250 T252 L295 R333 R334 R338

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3pw7, PDBe:3pw7, PDBj:3pw7
• PDBsum: 3pw7
• PubMed: 21790157
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)